GHRP-2

Published research reports that GHRP-2 binds the GHS-R1a receptor, the same receptor activated by the natural hormone ghrelin. In animal models and cell studies, that binding has been observed to trigger release of growth hormone from pituitary somatotroph cells, and researchers have reported that the effect is additive with growth hormone releasing hormone. GHRP-2 does not act on the GHRH receptor itself.

The primary research area for GHRP-2 is growth hormone secretion. In rodent studies and human clinical studies, researchers have reported that GHRP-2 produces a rapid rise in circulating growth hormone. Because of that response, GHRP-2 has been evaluated in clinical studies as a diagnostic stimulation agent for testing pituitary growth hormone secretion, and it is used in laboratories as a reference ghrelin receptor agonist.

Secondary research areas for GHRP-2 include appetite regulation, where animal studies have reported increased food intake consistent with ghrelin receptor activation, and cardiovascular research, where in vitro and animal work has examined ghrelin receptor signaling in heart tissue. Researchers have also studied GHRP-2 for its effects on cortisol and prolactin release, which are reported to be smaller than those of some older secretagogues.

GHRP-2 has been studied in vitro, in animal models, and in human clinical studies. It has been used as a diagnostic agent in some regions, and it is not an approved therapeutic drug. In the research market it serves as a well-characterized ghrelin receptor agonist. Biotech Compounds supplies GHRP-2 strictly for laboratory research into these reported observations.

GHRP-2 and GHRP-6 are both synthetic hexapeptide ghrelin receptor agonists. GHRP-6 is one of the earliest members of the family, while GHRP-2 was developed later with a D-2-naphthylalanine residue at position 2. Research studies have reported that GHRP-2 produces a stronger growth hormone response than GHRP-6, while GHRP-6 has been observed to produce a more pronounced increase in food intake in animal models.

GHRP-2 and Ipamorelin are both growth hormone secretagogues that act on the ghrelin receptor. Research studies have reported that Ipamorelin is more selective, producing growth hormone release with little effect on cortisol or prolactin, while GHRP-2 has been observed to produce a larger growth hormone pulse together with a modest rise in those hormones. Both are sold by Biotech Compounds as lyophilized research peptides.

GHRP-2 is supplied as a lyophilized powder that is soluble in sterile water or Bacteriostatic Water. Allow the vial to reach room temperature, then add the liquid slowly against the inner wall of the vial. Swirl gently until the solution is clear and never shake. As a short hexapeptide, GHRP-2 dissolves readily and normally gives a clear solution within a short time.

Store lyophilized GHRP-2 at -20 C, protected from light and moisture. After reconstitution, keep the solution refrigerated at 2 to 8 C, protect it from light, and avoid repeated freeze thaw cycles. The three D-amino acids in GHRP-2 were built in for metabolic stability, and research has reported that they slow enzymatic breakdown, but cold storage is still required for the reconstituted solution.

Yes. GHRP-2 from Biotech Compounds is supplied at 99 percent or greater purity. Each lot is third-party tested for identity and purity, and the Certificate of Analysis is available on the product page. Researchers can review the analytical data before using GHRP-2 in a receptor assay or animal model experiment.

GHRP-2 has a molecular weight of approximately 817.9 Da and the molecular formula C45H55N9O6. It is a six-residue peptide with an amidated C-terminus. Three of the residues are D-amino acids, D-Ala, D-2-naphthylalanine, and D-Phe, and the D-2-Nal at position 2 is the key structural feature that distinguishes GHRP-2 from GHRP-6.

No. GHRP-2 is sold by Biotech Compounds strictly as a research material for laboratory research by qualified researchers and research organizations. Purchasers must be 21 or older. GHRP-2 is not a drug or dietary supplement, is not approved by any regulatory agency as a therapeutic, and is not for human or animal consumption.