GLP-2T

In research studies, GLP-2T has been shown to bind both the GIP receptor and the GLP-1 receptor, two incretin receptors on pancreatic beta cells and other tissues. Researchers have reported that GLP-2T activates the GIP receptor with roughly native affinity while engaging the GLP-1 receptor with a weaker, biased signal. In animal models, this combined activity has been associated with glucose-dependent insulin secretion, reduced food intake, and changes in fat tissue metabolism.

GLP-2T contains a C20 fatty di-acid attached at lysine 20 through a glutamic acid linker. Published research suggests that this chain binds serum albumin, which extends the circulating lifetime of GLP-2T in research models. GLP-2T also carries alpha-aminoisobutyric acid substitutions in place of residues that the enzyme DPP-4 would otherwise cleave, and research studies have shown that these substitutions protect the peptide from rapid enzymatic breakdown.

The primary research area for GLP-2T is metabolic regulation, especially glucose homeostasis and body weight. In rodent models, researchers have reported that GLP-2T lowers blood glucose and reduces body weight more than a GLP-1 receptor agonist alone. Clinical trials of this dual agonist class have reported glycemic and weight outcomes. GLP-2T is chosen by researchers who want to study what adding GIP receptor activity contributes to GLP-1 receptor signaling.

GLP-2T has been examined in several secondary areas beyond glucose and weight. In research studies, dual GIP and GLP-1 receptor agonists have been evaluated for effects on liver fat, lipid profiles, and markers of insulin sensitivity in adipose tissue. Researchers have also reported cardiovascular and kidney marker data from clinical trial programs in this class. In animal models, GLP-2T has been studied for effects on energy expenditure and fat distribution.

GLP-2T has a deep evidence base for a research peptide. Research on this dual GIP and GLP-1 receptor agonist includes in vitro receptor binding studies, rodent and primate models, and phase 3 clinical trials in the metabolic field. Peptides of this exact structure have been the subject of completed clinical programs. The GLP-2T sold by Biotech Compounds is a research-grade material for laboratory study of the molecule, not a finished pharmaceutical.

GLP-1S is a single GLP-1 receptor agonist, while GLP-2T is a dual agonist that activates both the GIP receptor and the GLP-1 receptor. GLP-2T is a 39-amino acid peptide built on a GIP backbone, whereas GLP-1S is a 31-amino acid GLP-1 analog. In research studies, the added GIP receptor activity of GLP-2T has been associated with larger effects on body weight and glucose than GLP-1 receptor activation alone in comparable models.

GLP-2T targets two receptors, GIP and GLP-1, while GLP-3R is a triple agonist that adds the glucagon receptor to those two. In research studies, glucagon receptor activation has been linked to higher energy expenditure and liver fat reduction in animal models, so GLP-3R is used when that third pathway is of interest. GLP-2T is chosen when the study focuses on the incretin receptors alone without glucagon receptor involvement.

GLP-2T is supplied as a lyophilized powder that is reconstituted with bacteriostatic water or sterile water. The diluent is added slowly down the inside wall of the vial, and the vial is swirled gently until the GLP-2T powder dissolves. The vial must never be shaken, since vigorous agitation can damage the peptide. Because GLP-2T carries a fatty acid chain, a slightly longer swirling time may be needed for full dissolution.

Lyophilized GLP-2T should be stored frozen at minus 20 C and protected from light. After reconstitution, GLP-2T should be refrigerated at 2 to 8 C, kept away from light, and used within the timeframe set by the research protocol. Repeated freeze and thaw cycles should be avoided. Research studies have reported that the albumin-binding side chain gives GLP-2T an extended half-life in biological systems, but the vial still requires proper cold storage.

GLP-2T has a molecular weight of about 4813.5 g/mol and a molecular formula of C225H363N49O70. It is a 39-amino acid acylated peptide. Biotech Compounds supplies GLP-2T as a lyophilized powder with a purity of 98 percent or higher, confirmed by third-party testing. The Certificate of Analysis for each lot of GLP-2T is available on the product page so researchers can verify identity and purity before ordering.

No. GLP-2T is sold strictly as a research material for laboratory research by qualified researchers and research organizations. Purchasers must be 21 years of age or older. GLP-2T from Biotech Compounds is not a drug or a dietary supplement, it is not a substitute for any prescription product, and it is not for human or animal consumption.