Humanin
Humanin is a 24-amino acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 16S rRNA region. It is studied for its cytoprotective and anti-apoptotic signaling activity, particularly its interaction with pro-apoptotic Bcl-2 family proteins.
Product Details
Humanin (HN) was the first identified member of the mitochondrial-derived peptide (MDP) family, a class of small bioactive peptides encoded within the mitochondrial genome. Comprising 24 amino acids, Humanin functions as a signaling peptide with characterized cytoprotective properties across multiple cell types.
Its principal described mechanism is anti-apoptotic: Humanin binds and antagonizes pro-apoptotic Bcl-2 family members including Bax, Bid, and BimEL, suppressing mitochondrial-mediated apoptosis. It additionally signals through cell-surface receptor complexes (including the formyl peptide receptor–like 1 and the gp130/CNTFR/WSX-1 trimeric receptor), activating downstream STAT3 and other pro-survival pathways. Humanin has been examined in the context of neuronal viability, metabolic and insulin-related signaling, oxidative-stress modulation, and cardiomyocyte protection, and is of interest in the broader study of mitochondrial signaling and cellular stress resistance.
Disclaimer: This product is intended for laboratory and in-vitro use only. It is not for human consumption, ingestion, or any form of in-vivo administration in humans or animals. Not a drug, food, or dietary supplement. Handling should be performed only by qualified personnel.
