Research Compound
SLU-PP-332
SLU-PP-332 is a synthetic small molecule classified as an estrogen-related receptor (ERR) agonist, available as a lyophilized powder for laboratory research.
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5mg
SKU: 332
Batch: 202609-01-SLU
$64.99
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Est. Arrival: 09/18/2026
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For Research Use Only. This product is intended for laboratory and scientific research purposes only. It is not a drug or dietary supplement and is not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease.
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Product Details
SLU-PP-332 is a synthetic small molecule pan-agonist of the estrogen-related receptors (ERRα, ERRβ, ERRγ; NR3B1–3), with greatest potency at ERRα. ERRs are orphan members of the nuclear receptor superfamily of ligand-activated transcription factors.
Functions through direct binding to the ERR ligand-binding domain, increasing transcription of genes governing mitochondrial biogenesis and fatty acid oxidation; studied in exercise-mimetic research models. Assess solubility in DMSO or aqueous solutions as needed. Store at -20°C protected from light.
Disclaimer: For laboratory and research purposes only. Not intended for human consumption.
Frequently Asked Questions About SLU-PP-332
Answers summarize published research and are provided for laboratory research purposes only.
SLU-PP-332 is a synthetic small molecule, not a peptide, that acts as an agonist of the estrogen-related receptors ERR alpha, ERR beta, and ERR gamma, with the strongest activity at ERR alpha. These receptors are orphan nuclear receptors that regulate energy metabolism. Research studies have examined SLU-PP-332 as an exercise mimetic in mouse models of endurance and metabolism. Biotech Compounds supplies SLU-PP-332 as a lyophilized powder for laboratory research.
Researchers have reported that SLU-PP-332 binds directly to the ligand binding domain of the estrogen-related receptors and switches on their transcriptional activity. In cell culture studies, this activation increased expression of genes that drive mitochondrial biogenesis and fatty acid oxidation, the same gene program that endurance exercise turns on in muscle. Published research describes SLU-PP-332 as pharmacologically mimicking part of the adaptive response to training.
The primary research area for SLU-PP-332 is exercise physiology. In mouse studies, researchers reported that animals given SLU-PP-332 ran longer and farther on a treadmill than controls and showed a higher proportion of oxidative, fatigue-resistant muscle fibers. Investigators also observed increased mitochondrial content in skeletal muscle. These findings led researchers to describe SLU-PP-332 as an exercise mimetic in the scientific literature.
Yes. A second research area for SLU-PP-332 is energy balance. In mouse models fed a high fat diet, researchers reported that SLU-PP-332 increased whole-body energy expenditure and fatty acid use and reduced fat mass gain without changing food intake. Studies have also examined effects on glucose handling in these animals. This work is used to explore how ERR activation changes metabolism in a laboratory setting.
SLU-PP-332 evidence is entirely preclinical. It comes from in vitro receptor assays, cell culture gene expression work, and mouse studies published by the academic group that designed the molecule. SLU-PP-332 has not been tested in human clinical trials and is not an approved drug anywhere. It is a relatively new investigational research compound, and researchers should treat published results as early-stage.
SLU-PP-332 and AICAR are both studied as exercise mimetics and both are sold by Biotech Compounds, but they act at different points. SLU-PP-332 is an ERR agonist that directly activates nuclear receptors controlling mitochondrial genes. AICAR is an AMP analog that activates the energy sensor AMPK, which sits upstream of those same gene programs. Research studies have examined each one separately, and some investigators compare them to see which pathway drives a given adaptation.
No. SLU-PP-332 is a small organic molecule with no amino acid chain, which sets it apart from most of the Biotech Compounds catalog. It is supplied as a lyophilized powder in a sealed vial at 99 percent or higher purity. Because it is not a peptide, SLU-PP-332 does not have the same sensitivity to shaking or enzymatic breakdown that peptides have, but it should still be handled with care to preserve purity.
SLU-PP-332 is a lipophilic small molecule, so solubility should be assessed for each experiment. Researchers commonly dissolve SLU-PP-332 in DMSO to make a concentrated stock and then dilute into the aqueous buffer or vehicle used in the study. Aqueous solutions can also be tested directly. A brief swirl or gentle vortex is acceptable for SLU-PP-332, and the solution should be inspected for undissolved material before use.
Lyophilized SLU-PP-332 should be stored at minus 20 C in a sealed vial and protected from light. Once dissolved, SLU-PP-332 stock solutions should be kept cold, protected from light, and divided into small aliquots so that repeated freeze and thaw cycles are avoided. DMSO stocks are commonly frozen. Keeping the compound dry and dark preserves the purity of SLU-PP-332 across a research project.
Yes. SLU-PP-332 from Biotech Compounds is listed at 99 percent or higher purity and is third-party tested to confirm identity and purity. A Certificate of Analysis for SLU-PP-332 is available on the product page so researchers can review the results for their lot. This documentation supports reproducible research and gives research organizations a quality record for their files.
SLU-PP-332 has the molecular formula C23H27NO3 and a molecular weight of approximately 365.47 g/mol. With a single nitrogen and three oxygens on a carbon-rich frame, it is a compact, lipophilic molecule, which is why solvents such as DMSO are used to prepare stock solutions. The low molecular weight of SLU-PP-332 is typical of a synthetic nuclear receptor ligand.
No. SLU-PP-332 is not an approved drug and is not a dietary supplement. Biotech Compounds sells SLU-PP-332 strictly as a research material for laboratory research by qualified researchers and research organizations. Purchasers must be 21 years of age or older. SLU-PP-332 is not intended for human or animal consumption and is not intended to diagnose, treat, cure, or prevent any disease.
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