SKU: H10≥ 99% HPLC
Research Compound · Research use only
HGH 191AAHGH 191AA is a synthetic 191-amino acid protein identical in sequence to human pituitary growth hormone (somatropin), available as a lyophilized powder for laboratory research.
4.1 on Trustpilot · 46 reviews$85.99/ vial · 10iu
In stockShips 10/14/2026 · Est. Arrival: 10/19/2026
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99%+ PurityHPLC · third-party
COA Includedlot 202609-01-HGH
USA BasedMidwest Region
For Research Use Only. This product is intended for laboratory and scientific research purposes only. It is not a drug or dietary supplement and is not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease.
Product Details
HGH 191AA is a synthetic protein consisting of 191 amino acids identical to endogenous human growth hormone (somatropin). Contains two disulfide bridges (Cys53-Cys165 and Cys182-Cys189) essential for proper folding.
Adopts four-helix bundle tertiary structure characteristic of the GH/prolactin/cytokine receptor family. Produced through recombinant DNA technology. Soluble in bacteriostatic water or sterile water. Store at -20°C protected from light.
Disclaimer: For laboratory and in-vitro use only. Not for human consumption, medical, or veterinary use.
Frequently Asked Questions About HGH 191AA
Answers summarize published research and are provided for laboratory research purposes only.
HGH 191AA is a recombinant 191-amino acid protein whose sequence is identical to human pituitary growth hormone, also called somatropin. It is produced through recombinant DNA technology rather than extracted from tissue. Research studies have examined HGH 191AA in models of growth, protein metabolism, body composition, and IGF-1 signaling. Biotech Compounds supplies HGH 191AA as a lyophilized powder for laboratory research.
In research studies, HGH 191AA has been shown to bind the growth hormone receptor, causing two receptor molecules to pair and activate the JAK2 and STAT5 signaling pathway. Researchers have reported that this signal drives production of insulin-like growth factor 1 in liver and other tissues, and that IGF-1 mediates many of the downstream effects seen in animal models. Published research also suggests that HGH 191AA acts directly on fat and muscle cells in cell culture.
The 191 in HGH 191AA refers to its full-length, native amino acid sequence. Research studies have shown that a truncated 192-amino acid variant with an extra methionine can trigger antibody formation in animal models, so the 191-amino acid form is considered the correct match to endogenous growth hormone. HGH 191AA contains two disulfide bridges, at Cys53 to Cys165 and Cys182 to Cys189, that research has shown are required for proper folding.
The primary research area for HGH 191AA is growth and body composition. In animal models, researchers have reported that HGH 191AA increases lean tissue mass, reduces fat mass, and raises circulating IGF-1. Clinical trials of recombinant growth hormone have reported effects on height in growth-deficient models and on body composition in adults with low growth hormone. HGH 191AA is the reference protein for any laboratory study of somatotropic signaling.
HGH 191AA has been studied in a number of secondary areas. Research studies have examined its effects on bone density, lipid metabolism, and glucose handling in animal models. In vitro studies have used HGH 191AA to characterize the growth hormone receptor and the structure of the hormone-receptor complex. Researchers have also reported work on HGH 191AA in aging models, cardiac tissue, and wound tissue in animals.
HGH 191AA is one of the most thoroughly studied recombinant proteins in biology. Its structure has been solved by crystallography, its receptor has been mapped in vitro, and it has been studied in rodent and primate models for decades. Recombinant somatropin of the same sequence has been through extensive clinical trials. The HGH 191AA sold by Biotech Compounds is a research-grade protein for laboratory study, not a pharmaceutical product.
HGH 191AA is the growth hormone protein itself, while Sermorelin is a 29-amino acid fragment of growth hormone releasing hormone. In research studies, Sermorelin has been shown to act on the pituitary to stimulate release of endogenous growth hormone in a pulsatile pattern. HGH 191AA supplies the hormone directly and bypasses the pituitary. Researchers choose Sermorelin to study pituitary regulation and HGH 191AA to study growth hormone action itself.
Ipamorelin and CJC-1295 are secretagogues, meaning research studies have shown they prompt the pituitary to release its own growth hormone. Ipamorelin acts on the ghrelin receptor and CJC-1295 on the GHRH receptor. HGH 191AA is the finished 191-amino acid hormone. In animal models, researchers have reported that secretagogues preserve the natural pulsatile release pattern, while HGH 191AA produces a direct, dose-dependent rise in circulating growth hormone.
HGH 191AA is supplied as a lyophilized powder and is reconstituted with bacteriostatic water or sterile water. The diluent is added slowly down the inside wall of the vial and the vial is rocked or swirled very gently until the powder dissolves. HGH 191AA is a folded protein with disulfide bridges, so it must never be shaken, since foaming and mechanical stress can denature the protein and reduce activity.
Lyophilized HGH 191AA should be stored frozen at minus 20 C and protected from light. Once reconstituted, HGH 191AA should be kept refrigerated at 2 to 8 C, protected from light, and used within the timeframe set by the research protocol. Repeated freeze and thaw cycles must be avoided because they unfold the four-helix bundle structure. Research studies have reported that native growth hormone has a short half-life in circulation, measured in minutes, which is separate from its stability in the vial.
HGH 191AA has a molecular weight of 22,125.12 g/mol and a molecular formula of C990H1529N263O300S7. It is a 191-amino acid single-chain protein with two disulfide bridges. Biotech Compounds supplies HGH 191AA as a lyophilized powder with a purity of 99 percent or higher, confirmed by third-party testing. The Certificate of Analysis for each lot of HGH 191AA is available on the product page.
No. HGH 191AA is sold strictly as a research material for laboratory and in vitro research by qualified researchers and research organizations. Purchasers must be 21 years of age or older. HGH 191AA from Biotech Compounds is not a drug or a dietary supplement, is not for medical or veterinary use, and is not for human or animal consumption.
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