PE-22-28

PE-22-28 is a seven-amino-acid synthetic peptide derived from spadin, a naturally secreted peptide cleaved from the propeptide region of sortilin in the central nervous system. The peptide corresponds specifically to the 22nd through 28th residues of the spadin sequence — the origin of its name — and was identified through screening of spadin's blood-degradation products as the minimal, most efficient sequence capable of blocking the TREK-1 channel.

TREK-1 (a TWIK-related potassium channel) is a two-pore-domain potassium channel concentrated in brain regions governing mood, memory, and learning, and it has been characterized as a target of interest in depression models. By antagonizing TREK-1, PE-22-28 modulates neuronal excitability and downstream signaling. In comparative work it demonstrated markedly greater specificity and affinity for the channel than spadin itself (reported IC₅₀ on the order of 0.12 nM versus 40–60 nM for spadin), along with substantially improved in-vivo stability — extending its functional window to roughly 23 hours against spadin's ~7 hours.

Beyond channel inhibition, PE-22-28 is associated with the promotion of neurogenesis and synaptogenesis, with reported induction of new neuronal growth after only a few days and increased expression of the synaptic marker PSD-95. These properties have made it a compound of interest in models of antidepressant activity, learning, stroke recovery, and neurodegenerative conditions. CAS No.: 1801959-12-5.

Disclaimer: This product is intended for laboratory and research use only. It is not for human consumption, not a drug, and not intended to diagnose, treat, cure, or prevent any disease. Not for therapeutic, diagnostic, cosmetic, or any in-vivo use in humans or animals.