Research Compound
Thymosin Alpha-1
Thymosin Alpha-1 is a 28-amino acid synthetic peptide corresponding to the natural thymic peptide sequence, available as a lyophilized powder for laboratory research.
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10mg
SKU: TA10
Batch: 202610-01-TA
$96.99
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For Research Use Only. This product is intended for laboratory and scientific research purposes only. It is not a drug or dietary supplement and is not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease.
99%+ Purity
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Product Details
Thymosin Alpha-1 is a synthetic 28-amino acid peptide with the sequence Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH. It corresponds to the N-terminal region of prothymosin alpha, originally isolated from bovine thymus tissue.
The peptide is acetylated at its N-terminus and contains a high proportion of acidic amino acid residues, giving it a net negative charge at physiological pH. Provided as a lyophilized powder, freely soluble in sterile water or bacteriostatic water. Store at -20°C protected from moisture.
Disclaimer: For laboratory and research purposes only. Not intended for human consumption.
Frequently Asked Questions About Thymosin Alpha-1
Answers summarize published research and are provided for laboratory research purposes only.
Thymosin Alpha-1 is a synthetic 28 amino acid peptide that matches the N-terminal region of prothymosin alpha, a protein originally isolated from bovine thymus tissue. It is acetylated at the N-terminus and rich in acidic residues, giving it a net negative charge at physiological pH. Research studies have examined Thymosin Alpha-1 primarily in immunology, including T-cell maturation, dendritic cell activation, and immune response in models of infection and vaccination.
Research studies have shown that Thymosin Alpha-1 engages toll like receptors on dendritic cells and other innate immune cells, signaling through pathways that lead to NF-kB activation. Researchers have reported that this promotes dendritic cell maturation and the production of cytokines that steer T-cell differentiation. In cell culture, Thymosin Alpha-1 has been observed to increase markers of T-cell activation and to support natural killer cell activity in the models tested.
The primary research area for Thymosin Alpha-1 is immune modulation. In animal models, researchers have reported that Thymosin Alpha-1 increased T-cell counts and improved measures of immune response in models where immune function had been suppressed. Clinical trials have examined Thymosin Alpha-1 as an adjunct in immune research settings, including models of viral infection. This work has made Thymosin Alpha-1 one of the most studied thymic peptides.
Secondary research on Thymosin Alpha-1 includes vaccine adjuvant studies, where researchers have reported stronger antibody responses in animal models when Thymosin Alpha-1 was included alongside the antigen. Published research has also examined Thymosin Alpha-1 in sepsis models, in fungal challenge models, and in oncology immunology, where it has been studied for effects on tumor infiltrating immune cells. These secondary literatures are smaller than the core immune modulation work.
Thymosin Alpha-1 has a broad evidence base that includes in vitro cell culture, animal models, and multiple human clinical trials. A pharmaceutical form of the peptide, known as thymalfasin, has been approved in a number of countries outside the United States for specific indications. It is not approved by the FDA. The Thymosin Alpha-1 supplied by Biotech Compounds is a research grade lyophilized peptide intended for laboratory investigation only.
Thymosin Alpha-1 and TB-500 share the thymosin name but are unrelated in function. Thymosin Alpha-1 is a 28 amino acid acetylated peptide that research studies have examined for immune signaling through toll like receptors. TB-500 is Thymosin Beta-4, a 43 amino acid actin binding peptide that researchers have studied in tissue repair and cell migration models. One is an immune modulator and the other is a cytoskeletal regulator, so the two are studied in different fields.
Thymosin Alpha-1 and Thymogen are both thymus derived research peptides, but Thymosin Alpha-1 is 28 amino acids long while Thymogen is a two amino acid dipeptide, Glu-Trp. Research studies have associated Thymosin Alpha-1 with dendritic cell maturation and toll like receptor signaling. Thymogen has been studied for its effect on T-cell precursor differentiation as a Khavinson bioregulator. Researchers comparing thymic signaling molecules often run Thymosin Alpha-1 and Thymogen in parallel.
Thymosin Alpha-1 is supplied as a lyophilized powder and is freely soluble in sterile water or Bacteriostatic Water. To reconstitute, the diluent is added slowly down the inner wall of the vial so it flows onto the Thymosin Alpha-1 powder without splashing. The vial is then gently swirled or rolled until the solution is clear. The vial should never be shaken, since agitation can damage the peptide and create foam.
Lyophilized Thymosin Alpha-1 should be stored at minus 20 C in a sealed vial, protected from moisture and light. After reconstitution, Thymosin Alpha-1 solution should be refrigerated at 2 to 8 C, protected from light, and used within a short period. Freeze thaw cycles should be avoided. Pharmacokinetic research has reported that Thymosin Alpha-1 has a short circulating half-life measured in hours, which is why fresh solution is preferred in laboratory protocols.
Yes. Thymosin Alpha-1 from Biotech Compounds is listed at 99 percent or higher purity and every lot is tested by an independent laboratory. The Certificate of Analysis for Thymosin Alpha-1 is available on the product page and reports identity and purity results for the batch. Researchers should confirm that the lot number on the Thymosin Alpha-1 vial matches the posted COA before beginning an experiment.
Thymosin Alpha-1 has a molecular weight of approximately 3108.3 g/mol and the molecular formula C129H215N33O55. It is a 28 amino acid peptide beginning with an acetylated serine and ending with a free asparagine. The sequence contains a high proportion of glutamic acid and aspartic acid residues, which is why Thymosin Alpha-1 carries a strong negative charge in solution and dissolves so readily in water.
No. Thymosin Alpha-1 from Biotech Compounds is sold strictly as a research material for laboratory research by qualified researchers and research organizations. Purchasers must be 21 years of age or older. The Thymosin Alpha-1 sold here is not a drug or a dietary supplement, is not the pharmaceutical product approved in other countries, and is not for human or animal consumption. It is intended only for laboratory investigation.
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