Biotech Compounds
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Eloralintide
Research Compound

Eloralintide

Eloralintide is a synthetic 37-amino acid acylated analog of human amylin, classified as a selective amylin receptor agonist, available as a lyophilized powder for laboratory research.

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10mg
SKU: ELOR10
Batch: 202610-01-ELOR
$149.99
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For Research Use Only. This product is intended for laboratory and scientific research purposes only. It is not a drug or dietary supplement and is not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease.
99%+ Purity
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Categories:
HormonalTherapeutic
Tags:
eloralintideamylin analogamylin receptor agonistAMY1Racylated peptide37-amino acidappetite regulationsatietymetabolicweight management

Product Details

Eloralintide is a synthetic 37-amino acid analog of human amylin, the pancreatic islet hormone co-secreted with insulin from beta cells. It is supplied as a lyophilized powder for laboratory research.


Structure. The peptide is C-terminally amidated and constrained by a methylene bridge between Cys2 and Cys7 in place of the native disulfide. Ornithine at position 11, alpha-methyl-phenylalanine at position 15 and N-methyl-asparagine at position 22 replace the corresponding native residues to limit proteolysis and aggregation. A C20 fatty diacid is attached at Lys26 through a gamma-Glu-gamma-Glu linker, a lipidation strategy used to promote reversible serum albumin binding and prolong circulating exposure.


Receptor profile. Amylin receptors are heterodimers of the calcitonin receptor paired with a receptor activity modifying protein, giving AMY1R, AMY2R and AMY3R. Eloralintide behaves as a full agonist across the human receptor set with a reported EC50 of 23.9 pM at AMY1R and 253.8 pM at AMY3R, roughly 11 to 12 fold selectivity for AMY1R over AMY3R and over the unmodified calcitonin receptor. That receptor bias is the structural distinction from dual amylin and calcitonin receptor agonists, which engage the calcitonin receptor with comparable potency.


Research context. Amylin signaling in the area postrema and nucleus of the solitary tract is studied in connection with meal termination, satiation signaling, gastric emptying and glucagon regulation. Selective amylin receptor agonists are used to separate amylin-mediated effects from calcitonin receptor engagement, and to examine amylin pathway pharmacology alone or alongside incretin receptor agonist mechanisms in metabolic research models.


Handling. Molecular formula C201H319N49O65S2, molecular weight 4,526.10 g/mol, CAS 2883634-40-8. Purity 99 percent or greater by HPLC with a certificate of analysis. Store the sealed lyophilized vial at -20°C away from moisture and light. Reconstitute with bacteriostatic or sterile water directed against the inner wall of the vial, swirl gently rather than shaking, and hold reconstituted material at 2 to 8°C.


Frequently Asked Questions


What is Eloralintide?

Eloralintide is a synthetic 37-amino acid analog of human amylin engineered for selective activation of the amylin 1 receptor. It is supplied as a lyophilized research powder in a 10mg vial.


Eloralintide vs Cagrilintide: what is the difference?

Both are lipidated long-acting synthetic amylin analogs, and both carry a C20 fatty diacid for albumin binding, but they are built to different receptor targets. Cagrilintide is a 39-amino acid dual amylin and calcitonin receptor agonist, meaning it activates the amylin receptors and the calcitonin receptor at comparable potency. Eloralintide is a 37-amino acid selective amylin receptor agonist that favors AMY1R by roughly 11 to 12 fold over AMY3R and over the calcitonin receptor. Structurally, eloralintide keeps the native 37-residue amylin length with a methylene bridge replacing the Cys2-Cys7 disulfide plus three non-canonical residues, while cagrilintide extends the backbone to 39 residues and retains a Cys3-Cys8 disulfide. In published preclinical comparisons the selective profile tracked with less conditioned taste avoidance at a comparable body-weight effect, which is the mechanistic question most laboratory comparisons of the two compounds are designed to probe.


What is the molecular formula and molecular weight?

The molecular formula is C201H319N49O65S2 and the molecular weight is 4,526.10 g/mol. CAS number 2883634-40-8.


Why is Eloralintide described as selective?

Amylin receptors are formed when the calcitonin receptor pairs with a RAMP accessory protein, so the calcitonin receptor is the shared core and most amylin analogs also activate it. Eloralintide was optimized to preferentially activate the RAMP1-containing AMY1R complex, which lets investigators attribute an observed effect to amylin receptor signaling rather than to calcitonin receptor activity.


How should this material be stored and reconstituted?

Keep the sealed vial at -20°C, protected from moisture and light. Reconstitute with bacteriostatic or sterile water, adding the diluent slowly against the inner wall of the vial and swirling rather than shaking to avoid shearing the peptide. Hold the reconstituted solution at 2 to 8°C and avoid repeated freeze-thaw cycles.


Is a certificate of analysis included?

Yes. Every lot ships with third-party analysis covering identity, content and purity, and lot certificates are published on the Certificates of Analysis page.


Can Eloralintide be studied alongside incretin receptor agonists?

Amylin pathway pharmacology is frequently examined in parallel with GLP-1 and GIP receptor agonist mechanisms in metabolic research models, because the pathways act through distinct receptor families. Any such work is laboratory research only.


Is this product intended for human use?

No. This is a research chemical supplied for laboratory and scientific use only.


Disclaimer: For laboratory research purposes only. Not intended for human consumption. This material is not a drug, food or dietary supplement, is not approved for human, veterinary or household use, and is not intended to diagnose, treat, cure or prevent any disease.

Frequently Asked Questions About Eloralintide

Answers summarize published research and are provided for laboratory research purposes only.

Eloralintide is a synthetic 37-amino acid acylated analog of human amylin, the pancreatic hormone released alongside insulin from islet beta cells. It is classified as a long-acting amylin receptor agonist research peptide with selectivity for the AMY1R receptor. Biotech Compounds supplies Eloralintide as a lyophilized powder at 99 percent or greater purity for laboratory research.
Amylin receptors form when the calcitonin receptor pairs with a receptor activity modifying protein, producing AMY1R, AMY2R, and AMY3R. In vitro receptor studies have reported that Eloralintide acts as a full agonist across the human amylin receptor set while favoring AMY1R over AMY3R and over the unmodified calcitonin receptor. Researchers use that bias to attribute an observed effect to amylin receptor signaling.
The primary research area for Eloralintide is amylin pathway pharmacology in metabolic models. In animal models and clinical trials, researchers have examined how selective amylin receptor activation relates to satiation signaling, meal termination, gastric emptying, and body weight regulation. Published research has also looked at whether selective AMY1R engagement separates the appetite signal from aversive responses seen with less selective amylin analogs.
Beyond appetite and body weight models, Eloralintide has been studied in connection with glucagon regulation and glucose handling, because amylin signaling in the area postrema and nucleus of the solitary tract is reported to influence these pathways. Research studies have also examined Eloralintide alongside incretin receptor agonists to explore whether amylin and incretin pathways act through independent receptor families in metabolic research models.
Eloralintide is an investigational compound. The available evidence includes in vitro receptor pharmacology, preclinical animal model studies, and clinical trials that have been reported in the scientific literature. It is not an approved medicine anywhere. Biotech Compounds supplies Eloralintide only so laboratories can investigate selective amylin receptor pharmacology, and no research finding should be read as a promise of any outcome.
Eloralintide and Cagrilintide are both lipidated long-acting synthetic amylin analogs carrying a C20 fatty diacid for albumin binding. Cagrilintide is a 39-amino acid dual amylin and calcitonin receptor agonist that engages both receptor types at similar potency. Eloralintide keeps the native 37-residue amylin length and is a selective amylin receptor agonist that favors AMY1R. Preclinical comparisons have reported that the selective profile tracked with less conditioned taste avoidance.
Eloralintide is supplied as a lyophilized powder in a sealed vial. To reconstitute, add Bacteriostatic Water or sterile water slowly against the inner wall of the vial rather than directly onto the powder. Swirl the vial gently until the solution is clear and never shake it, because shear can damage the peptide. Let the vial reach room temperature before opening to limit condensation.
Store the sealed lyophilized Eloralintide vial at -20 C, protected from moisture and light. Once reconstituted, keep the solution refrigerated at 2 to 8 C, protect it from light, and avoid repeated freeze thaw cycles. The C20 fatty diacid on Eloralintide is a lipidation strategy that research has reported extends circulating exposure through reversible albumin binding, but that does not change the need for cold storage.
Yes. Every lot of Eloralintide sold by Biotech Compounds is third-party tested for identity, content, and purity, with purity of 99 percent or greater by HPLC. The Certificate of Analysis for the lot is available on the product page and on the Certificates of Analysis page, so a researcher can confirm the analytical results before using the material in an experiment.
Eloralintide has a molecular weight of 4,526.10 g/mol and the molecular formula C201H319N49O65S2. The 37-residue peptide is C-terminally amidated, carries a methylene bridge between Cys2 and Cys7 in place of the native disulfide, and includes ornithine, alpha-methyl-phenylalanine, and N-methyl-asparagine substitutions that research has reported limit proteolysis and aggregation.
Most amylin analogs also activate the calcitonin receptor because it is the shared core of every amylin receptor complex. Eloralintide was optimized so that it preferentially activates the RAMP1-containing AMY1R complex. In vitro pharmacology studies have reported roughly 11 to 12 fold selectivity for AMY1R over AMY3R and the calcitonin receptor, which is why Eloralintide is described as selective.
No. Eloralintide is sold by Biotech Compounds strictly as a research material for laboratory research by qualified researchers and research organizations. Purchasers must be 21 or older. Eloralintide is not a drug or dietary supplement, has not been approved by any regulatory agency, and is not for human or animal consumption.
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