Relaxation PMRelaxation PM (RP226) is a four-component liquid research formulation containing GABA (100 mg/mL), L-arginine (100 mg/mL), L-glutamine (25 mg/mL), and melatonin (1 mg/mL) at a combined 226 mg/mL in a 10 mL vial. Supplied for laboratory research on inhibitory neurotransmission, nitric oxide chemistry, and circadian signaling. Research use only. Not for human or animal consumption.

Relaxation PM, catalog RP226, is a four-component liquid research formulation built around compounds that neuroscience and chronobiology literature associate with the evening and rest phase of the daily cycle. It combines an inhibitory neurotransmitter, two amino acids that feed the nitric oxide and glutamate-GABA pathways, and the pineal indoleamine melatonin. Total solute concentration is 226 mg/mL, supplied in a 10 mL vial for laboratory research.

Active Ingredients (per mL)

GABA, Gamma-Aminobutyric Acid (100mg/mL) — The chief inhibitory neurotransmitter of the mammalian central nervous system. GABA is a non-proteinogenic four-carbon amino acid formed from glutamate by glutamic acid decarboxylase, and it acts on the ionotropic GABA-A chloride channel and the metabotropic GABA-B receptor. It is a standard reference compound in receptor binding work, electrophysiology, and amino acid neurotransmitter analysis.

L-Arginine (100mg/mL) — A guanidino amino acid that nitric oxide synthase oxidizes to nitric oxide and citrulline. In the research setting it is the reference substrate for NOS activity measurement, and it is also used to study arginase competition and the vascular signaling cascade that runs through soluble guanylate cyclase and cGMP.

L-Glutamine (25mg/mL) — The most abundant free amino acid in plasma and the carrier of nitrogen between tissues. In neurochemistry it is one leg of the glutamate-glutamine cycle: astrocytes convert glutamate to glutamine, and neurons convert glutamine back to glutamate, which can then be decarboxylated to GABA. That places it directly upstream of the GABA in this blend.

Melatonin (1mg/mL) — N-acetyl-5-methoxytryptamine, an indoleamine synthesized from serotonin in the pineal gland on a night-time schedule. It signals through the MT1 and MT2 G protein-coupled receptors and is the reference compound in circadian rhythm and chronobiology research. Melatonin is light-sensitive and only sparingly water-soluble, which is why it is the smallest component by mass.

Together the four components span an amino acid neurotransmitter, two of its metabolic neighbors, and an indoleamine hormone. That gives researchers one matrix for studying inhibitory signaling, the glutamine to glutamate to GABA route, nitric oxide generation, and circadian receptor pharmacology, and for analytical work such as multi-analyte chromatographic separation and stability testing of a mixed amino acid and indole solution.

Disclaimer: Relaxation PM is supplied strictly for research and laboratory use only. This product is not a drug, dietary supplement, sleep aid, or medical device. It is not intended for human or animal consumption, and not for therapeutic, diagnostic, or clinical application. It has not been evaluated by the FDA, and no statement here should be read as a claim to diagnose, treat, cure, or prevent any condition. All handling should be performed by qualified researchers in accordance with applicable laboratory safety protocols and institutional guidelines.