Adamax
Adamax (Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Ala-Gly-NH2) is a synthetic nine-amino-acid peptide and structural analog of Semax, which is itself derived from the ACTH(4-10) fragment. It carries two defining structural modifications: an N-terminal acetyl group and a bulky lipophilic C-terminal adamantane (diamondoid) group, the motif characteristic of Peptide 021. Both modifications are studied in vitro for the resistance they confer to exopeptidase cleavage and for their effect on measured peptide half-life in serum-stability assays. Supplied as a lyophilized reference material for peptide chemistry, proteolytic-stability and degradation assays, cell-culture receptor-binding studies, and HPLC or LC-MS/MS identity and purity determination. For research and laboratory use only; not for human or animal consumption.
Product Details
Adamax is a nine-amino-acid synthetic peptide (Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Ala-Gly-NH2) structurally derived from Semax, itself an analog of the ACTH(4-10) fragment originally characterized at the Institute of Molecular Genetics of the Russian Academy of Sciences. Adamax differs from the parent Semax sequence at both termini: an acetyl group is placed on the N-terminus, forming the N-acetyl-Semax intermediate, and a bulky lipophilic adamantane diamondoid group is placed on the C-terminus — the structural motif characteristic of Peptide 021.
These two modifications define the chemistry of the molecule. N-terminal acetylation caps the free alpha-amine and reduces susceptibility to aminopeptidase cleavage, while the adamantane group provides steric bulk that shields the C-terminus from carboxypeptidase activity. In in vitro degradation panels and serum-stability assays these features are the variables under study when comparing measured half-life against the unmodified Semax sequence; the adamantane group additionally raises the lipophilicity of the molecule, a parameter commonly assessed in permeability and partition-coefficient assays.
In cell-culture and receptor work Adamax is used as a tool compound for in vitro investigation of brain-derived neurotrophic factor (BDNF) expression and TrkB receptor binding in cultured cell systems, along with dopaminergic and serotonergic receptor interactions measured in binding panels. Its fully defined sequence and terminal modifications also make it a useful reference standard in reversed-phase HPLC and LC-MS/MS work, including retention-time matching, structural confirmation of acetylation and adamantane conjugation, and purity determination.
Disclaimer: Adamax is supplied strictly for research and laboratory use only. This product is not a drug, dietary supplement, or medical device. It is not intended for human or animal consumption, and not for therapeutic, diagnostic, or clinical application. It has not been evaluated by the FDA, and no statement here should be read as a claim to diagnose, treat, cure, or prevent any condition. All handling should be performed by qualified researchers in accordance with applicable laboratory safety protocols and institutional guidelines.
