Name: PT-141
Brand: Biotech Compounds
Price: 64.99 USD
Availability: InStock
Rating: 4.8 (127 reviews)

Question 1

What is PT-141 and what has research studied it for?

Accepted Answer

PT-141, also known as bremelanotide, is a synthetic cyclic heptapeptide that acts as a melanocortin receptor agonist. It is a metabolite of Melanotan 2 formed by cleavage at the C-terminus. Research studies have examined PT-141 primarily in models of sexual response and arousal, and secondarily in studies of appetite and energy balance through the melanocortin system. Biotech Compounds supplies PT-141 as a lyophilized powder for laboratory research.

Question 2

How does PT-141 work according to research?

Accepted Answer

PT-141 binds melanocortin receptors, with reported affinity for MC1R, MC3R, MC4R, and MC5R. Researchers have reported that the effects of PT-141 on sexual response are driven mainly by MC4R activation in the central nervous system, particularly in hypothalamic pathways, rather than by action on blood vessels. In research studies this central mechanism distinguishes PT-141 from compounds that act on peripheral blood flow.

Question 3

What has research reported about PT-141 and sexual response?

Accepted Answer

The primary research area for PT-141 is sexual function. In rodent models, researchers observed increased solicitation and mounting behaviors after PT-141 administration. Clinical trials in humans have also evaluated PT-141 and reported changes in measures of desire and arousal compared with placebo. These trials are the reason PT-141 is the most clinically studied compound in the melanocortin class.

Question 4

What is the difference between PT-141 and Melanotan 2?

Accepted Answer

PT-141 and Melanotan 2 are closely related melanocortin agonists sold by Biotech Compounds. Melanotan 2 is the parent cyclic peptide, and PT-141 is its metabolite with the C-terminal amide removed. Research studies have reported that Melanotan 2 produces strong pigmentation effects through MC1R, while PT-141 has been studied mainly for its central MC4R effects on sexual response with less pigmentation activity. Researchers pick one depending on which receptor pathway they are studying.

Question 5

What type of evidence exists for PT-141?

Accepted Answer

PT-141 has one of the deepest evidence bases in the peptide research catalog. It has been studied in cell receptor binding assays, in rodent behavioral models, and in multiple human clinical trials including late-phase controlled studies. A pharmaceutical form of bremelanotide has been approved as a prescription drug in the United States. The PT-141 sold by Biotech Compounds is a research material and is not that pharmaceutical product.

Question 6

Why is PT-141 a cyclic peptide and what does that change?

Accepted Answer

PT-141 is cyclized through a lactam bridge between the side chains of aspartic acid and lysine, and it contains norleucine at position 1 and D-phenylalanine at position 4. Researchers have reported that this ring structure and the unnatural amino acids make PT-141 far more resistant to enzymatic breakdown than a linear peptide, which is what gives PT-141 a longer duration of action in research models.

Question 7

How is PT-141 reconstituted for research?

Accepted Answer

PT-141 is supplied as a lyophilized powder that dissolves in sterile water or Bacteriostatic Water. For laboratory preparation, the water is added slowly down the inside of the vial so it does not hit the powder directly. The vial is swirled gently until the solution is clear. PT-141 should never be shaken. Wiping the stopper with an alcohol wipe before drawing solution helps keep the reconstituted PT-141 sterile.

Question 8

How should PT-141 be stored before and after reconstitution?

Accepted Answer

Lyophilized PT-141 should be stored at minus 20 C and protected from light. After reconstitution, PT-141 should be refrigerated at 2 to 8 C, kept away from light, and used within a limited window. Repeated freezing and thawing should be avoided. Because PT-141 is cyclic, it is more stable in solution than many linear peptides, but cold, dark storage remains the standard laboratory practice.

Question 9

Is PT-141 third-party tested and does it have a Certificate of Analysis?

Accepted Answer

Yes. PT-141 from Biotech Compounds is listed at 99 percent or higher purity and is third-party tested to confirm identity and purity. A Certificate of Analysis for PT-141 is available on the product page so researchers can review the results for each lot. This documentation supports reproducible experiments and provides research organizations with a quality record for their files.

Question 10

What is the molecular weight and formula of PT-141?

Accepted Answer

PT-141 has the molecular formula C50H68N14O10 and a molecular weight of approximately 1025.2 Da. Its full structure is written Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH, with an acetylated N-terminus and a free C-terminal acid. The seven residues, the lactam bridge, and the D-amino acid together account for the mass of PT-141 and its stability in laboratory studies.

Question 11

Is PT-141 from Biotech Compounds approved for human use?

Accepted Answer

No. The PT-141 sold by Biotech Compounds is not an approved drug and is not a dietary supplement. It is sold strictly as a research material for laboratory research by qualified researchers and research organizations. Purchasers must be 21 years of age or older. PT-141 from Biotech Compounds is not intended for human or animal consumption and is not intended to diagnose, treat, cure, or prevent any disease.

PT-141PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide classified as a melanocortin receptor agonist, available as a lyophilized powder for laboratory research.

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