CBL-514CBL-514 is a synthetic small-molecule lipolysis research compound studied for its ability to induce apoptosis in adipocytes, available as a lyophilized powder for laboratory research.

CBL-514 is a synthetic small-molecule investigational compound studied as an injectable lipolysis agent. It is supplied as a lyophilized powder in a 60mg vial for laboratory research.

Mechanism in research. In published preclinical work CBL-514 has been reported to reduce adipocyte number by inducing apoptosis, programmed cell death, in fat cells, rather than by lysing cell membranes. That distinguishes it in the literature from detergent-type agents such as deoxycholic acid, which disrupt adipocyte membranes non-selectively and are associated with local necrosis and inflammation. Researchers use CBL-514 to examine apoptosis-driven reduction of subcutaneous adipose tissue and the local tissue response that follows.

Research context. CBL-514 has been evaluated in clinical-stage research on localized subcutaneous fat reduction, most often in the abdomen, and has also been studied in cellulite research. Laboratory work with the compound centers on adipocyte biology, lipolysis, adipose tissue remodeling and body-contouring models. Findings remain investigational and CBL-514 is not approved by any regulatory agency.

Handling. Purity 99 percent or greater with a certificate of analysis. Store the sealed lyophilized vial at -20°C away from moisture and light. Reconstitute with bacteriostatic or sterile water directed against the inner wall of the vial, swirl gently rather than shaking, and hold reconstituted material at 2 to 8°C.

Frequently Asked Questions

What is CBL-514?

CBL-514 is a synthetic small-molecule lipolysis compound studied for inducing adipocyte apoptosis. It is supplied as a lyophilized research powder in a 60mg vial.

Is CBL-514 a peptide?

No. CBL-514 is a small molecule, not a peptide, although it is supplied and handled in the same lyophilized vial format as our research peptides.

CBL-514 vs deoxycholic acid: what is the difference?

Deoxycholic acid is a bile acid that acts as a detergent, breaking down adipocyte membranes directly, which research associates with local necrosis and inflammation. CBL-514 has been reported in preclinical research to reduce fat cells through apoptosis instead, which is the mechanistic contrast most laboratory comparisons of the two are designed to probe.

How should this material be stored and reconstituted?

Keep the sealed vial at -20°C, protected from moisture and light. Reconstitute with bacteriostatic or sterile water, adding the diluent slowly against the inner wall of the vial and swirling rather than shaking. Hold the reconstituted solution at 2 to 8°C and avoid repeated freeze-thaw cycles.

Is a certificate of analysis included?

Yes. Every lot ships with third-party analysis covering identity, content and purity, and lot certificates are published on the Certificates of Analysis page.

Is this product intended for human use?

No. This is a research chemical supplied for laboratory and scientific use only.

Disclaimer: For laboratory research purposes only. Not intended for human consumption. This material is not a drug, food or dietary supplement, is not approved for human, veterinary or household use, and is not intended to diagnose, treat, cure or prevent any disease.